Aller au contenu Aller au menu Aller à la recherche

accès rapides, services personnalisés
Biologie Intégrative des Organismes Marins
UMR 7232




Nationality: Italian

Email: chi.sinigaglia @


ORCID iD: 0000-0002-7195-7091

Twitter: @chisinig




2022. CNRS researcher, grade CRCN, section 22.

April 2022. Group leader ATIP-Avenir, at theIntegrative Biology of Marine Organisms unit (BIOM UMR7232, Sorbonne University, CNRS), Observatoire Océanologique de Banyuls-sur-Mer (France).Team: Cnidarian regeneration, development and evolution.


April 2017 - April 2022. Post-doc, at the Institut de Génomique Fonctionnelle de Lyon (France), in the team of M. Averof.

Projects: i) Nerve control of limb regeneration in the crustacean Parhyale hawaiensis.  

             ii) Comparative transcriptomics of limb regeneration and development. 

March - Dec. 2014 and Nov. 2016 - March 2017. Post-doc within the ANR–MEDUSEVO project, at the Developmental Biology Laboratory of Villefranche-sur-Mer (France); pilot study on regeneration of the jellyfish Clytia. Team: E. Houliston/T. Momose.


Jan. 2015 - May 2016. Post-doc, project “Environmental sensitivity of the Delta/Notch-dependent germ stem cell niche in C. elegans” – Institut de Biologie Valrose (Nice, France). Team: C. Braendle.

Ligue Contre le Cancer fellowship.



2009–2013. PhD, University of Bergen/Sars International Centre for Marine Molecular Biology (Norway).

Thesis: The “anterior pole” of Metazoa: insights from the oral-aboral axis and the apical organ of the sea anemone Nematostella vectensis. Supervisor: Dr. Fabian Rentzsch.

Sept. 2008- Jan. 2009.Research fellowship, University of Padua (Italy).

Topic: sensory placode development in the larva of the colonial ascidian Botryllus schlosseri.

2006–2008. Master degree in Evolutionary biology, University of Padua (Italy). Final mark: 110/110 cum laude. Thesis: Muscle differentiation in a colonial ascidian: molecular and evolutionary aspects.

2003–2006. Bachelor degree in Biology, University of Padua (Italy). Final mark: 110/110 cum laude.

Thesis: Detection of E-selectin in the vascular apparatus of Botryllus schlosseri (Ascidiacea).



2019. EMBO Self-leadership Workshop for female scientists (Heidelberg, Germany) - 1 week.

2017. NEUBIAS Image Analysis schools, 11-14 September 2017 (Gothenburg, Sweden).

2015. Embryology: Concepts & Techniques in Modern Developmental Biology (Marine Biological

Laboratory, Woods Hole, USA) - 6 weeks.

2009. Gene Regulatory Network for Development (Marine Biological Laboratory, Woods Hole, USA) - 2 weeks.


  • SELECTED PUBLICATIONS                                                 

 * corresponding author, + equal contributions.


Sinigaglia C.*, Almazán A., Lebel M., Sémon M., Gillet B., Hughes S., Edsinger E., Averof M.*, Paris M.* (2022) “Distinct gene expression dynamics in developing and regenerating limbs.” PNAS 119 (27) e2119297119. doi: 10.1073/pnas.2119297119 .

Sinigaglia C., Alié A., Tiozzo S. (2022) “The hazards of regeneration: from Morgan’s legacy to benchwork”. Methods in Molecular Biology 2022;2450:3-25. doi: 10.1007/978-1-0716-2172-1_1 .

Sinigaglia C.+*, Peron S.+, Eichelbrenner J., Chevalier S., Steger J., Barreau C., Houliston E., Leclère L.* (2020)"Pattern regulation in a regenerating jellyfish”. eLife9:e54868 doi: 10.7554/eLife.54868.  

Averof M.*, Sinigaglia C.* (2020) “Introduction to emerging systems”. EvoDevo 11, 8. doi: 10.1186/s13227-020-00153-y .

Sinigaglia C.*, Averof M. (2019) "The multifaceted role of nerves in animal regeneration". Current Opinion in Genetics & Development 57, 98-105, 2019. doi: 10.1016/j.gde.2019.07.020.

Sinigaglia C.*, Thiel D., Hejnol A., Houliston E., Leclère L. (2018) "A safer, urea-based in situ hybridization method improves detection of gene expression in diverse animal species." Developmental Biology 434(1):15-23. doi: 10.1016/j.ydbio.2017.11.015.

Saina M., Busengdal H., Sinigaglia C., Petrone L., Oliveri P., Rentzsch F., Benton R. (2015) “Adevelopmental function for an insect gustatory receptor homologue in a cnidarian.” Nature Communications 18;6:6243. doi: 10.1038/ncomms7243.

Sinigaglia C., Busengdal H., Lerner A., Oliveri P., Rentzsch F. (2015) “Molecular characterization of the apical organ of the anthozoan Nematostella vectensisDevelopmental Biology 398:120-133. doi: 10.1016/j.ydbio.2014.11.019.

Sinigaglia C., Busengdal H., Leclère L., Technau U., Rentzsch F. (2013) “The Bilaterian head patterning gene six3/6 controls aboral domain development in a Cnidarian” PLoS Biology 11(2): e1001488. doi: 10.1371/journal.pbio.1001488.



2022. International Society for Regenerative Biology seminar. [Webinar]

2022. West Pacific Marine Biology Network seminar. [Webinar]

2022. 8th Euro Evo Devo meeting – Naples (Italy).

2022. Hopkins Marine Station, Stanford University (U.S.A.). [Webinar]

2021.  Sars International Centre for Marine Molecular Biology (Norway). [Webinar]

2020.  Whitney Laboratory for Marine Bioscience (U.S.A). [Webinar]

2016.  University of Padua – Padua (Italy).

2016.  Neptune ITN Symposium – Lisbon (Portugal).

2016.  Cambridge University – Cambridge (U.K.)



2021. Interview for The Scientist, in the article “How hydras regenerate decapitated heads”.

2020. Interview for the scientific program Les années lumière, of Radio Canada, regarding jellyfish


2020. Interview for Science Magazine, in the article “The more they eat, the more tentacles these sea anemones sprout”. doi:10.1126/science.abe7384

2020. Collaboration to the filming of an episode for the tv series Bestioles, with the French YouTuber Dr. Nozman and Pierre Kernel, introducing regeneration in Parhyale.

2018. Redaction of an article for the website Science Trends "When non-conventional research organisms drive change for standard laboratory techniques". doi: 10.31988/SciTrends.29275.

2017. Interview for the magazine Science et Vie, "L'hydre : quel est le secret de son éternelle jeunesse ?", published in July.

2007. RAI television program "Evoluti per caso – Sulla rotta di Darwin" (in Argentinian Patagonia) with University of Padua.






Traductions :