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accès rapides, services personnalisés
Biologie Intégrative des Organismes Marins
UMR 7232

Sébastien DARRAS


Téléphone : 04-30-19-24-09
Courriel(s) :

Fonction et rattachement

Chercheur DR2 CNRS

Chef d'équipe au BIOM depuis Mai 2012


  • Darras S., Marikawa Y., Elinson R.P. and Lemaire P.# (1997). Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser. Development. 124, 4275-4286. Link
  • Lemaire P.*#, Darras S.*, Caillol D.* and Kodjabachian L. (1998). A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone. Development.125, 2371-2380. Link
  • Darras S.# and Nishida H. (2001). The BMP signaling pathway is required together with the FGF pathway for notochord induction in the ascidian embryo. Development. 128, 2629-2638. Link
  • Darras S.# and Nishida H. (2001). The BMP/CHORDIN antagonism controls sensory pigment cell specification and differentiation in the ascidian embryo. Dev. Biol. 236, 271-288. Link
  • Akanuma T.#, Hori S., Darras S. and Nishida H. (2002). Notch signaling is involved in nervous system formation in ascidian embryos. Dev. Genes and Evol. 212, 459-472. Link
  • Hudson C.#, Darras S., Caillol D., Yasuo H. and Lemaire P.# (2003). A conserved role for the MEK signalling pathway in neural tissue specification and posteriorisation in the invertebrate chordate, the ascidian Ciona intestinalis. Development 130, 147-159. Link
  • Weninger W.J., Tassy O., Darras S., Geyer S.H. and Thieffry D.# (2004). From experimental imaging techniques to virtual embryology. Hist Philos Life Sci. 26, 355-375.
  • Pasini A.#, Amiel A., Rothbacher U., Roure A., Lemaire P. and Darras S.# (2006). Formation of the Ascidian Epidermal Sensory Neurons: Insights into the Origin of the Chordate Peripheral Nervous System. PLOS Biol. 27;4(7):e225. Link
  • Tassy O.*, Dauga D.*, Daian F.*, Sobral D.*, Robin F., Khoueiry P., Salgado D., Fox V., Caillol D., Schiappa R., Laporte B., Rios A., Luxardi G., Kusakabe T., Joly J.S., Darras S., Christiaen L., Contensin M., Auger H., Lamy C., Hudson C., Rothbächer U., Gilchrist M.J., Makabe K.W., Hotta K., Fujiwara S., Satoh N., Satou Y. and Lemaire P.# (2010). The ANISEED database: digital representation, formalization, and elucidation of a chordate developmental program. Genome Res. 20(10):1459-68. Link
  • Darras S.#, Gerhart J., Terasaki M., Kirschner M. and Lowe C.J.# (2011). β-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development 138, 959-970. Link
  • Roure A., Lemaire P. and Darras S.# (2014). An Otx/Nodal regulatory signature for posterior neural development in ascidians. PLOS Genet. 10(8):e1004548. Link
  • Roure A. and Darras S.# (2016). Msxb is a core component of the genetic circuitry specifying the dorsal and ventral neurogenic midlines in the ascidian embryo. Dev. Biol. 409, 277-287. Link
  • Darras S.#, Fritzenwanker J., Uhlinger K., Farrelly E., Pani A.M., Hurley I., Norris R., Osowitz M., Terasaki M., Wu M., Aronowicz J., Kirschner M., Gerhart J. and Lowe C.J.# (2018). Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development. PLOS Biology 16(1): e2003698.
  • Malfant M.#, Darras S. and Viard F.# (2018). Coupling molecular data and experimental crosses sheds light about species delineation: a case study with the genus Ciona. Sci. Rep. 8, 1480.
  • Alié A.*, Hiebert L.S.*, Simion P.*, Scelzo M., Prünster M.M., Lotito S., Delsuc F., Douzery E.J.P., Dantec C., Lemaire P., Darras S., Kawamura K., Brown F.D. and Tiozzo S.# (2018). Convergent acquisition of non-embryonic development in styelid ascidians. Mol. Biol. Evol. doi: 10.1093/molbev/msy068.
  • Feinberg S.*, Roure A.*, Piron J. and Darras S.# (2019). Antero-posterior ectoderm patterning by canonical Wnt signaling during ascidian development. PLOS Genetics 15, e1008054.
  • Coulcher J.F.*, Roure A.*, Chowdhury R., Robert M., Lescat L., Bouin A., Carvajal Cadavid J., Nishida H. and Darras S.# (2020). Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos. eLife 9, e59157.
  • Darras S.# (2021). En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embryos. Bio-protocol 11(18): e4160. DOI: 10.21769/BioProtoc.4160.
  • Chowdhury R.#, Roure A., le Pétillon Y., Mayeur H., Daric V. and Darras S.# (2022). Highly distinct genetic programs for peripheral nervous system formation in chordates. BMC Biol 20, 1–25.


(#: corresponding author; *: equal contribution)


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