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Integrative Biology of Marine Organisms
UMR 7232

Anne-Marie Genevière, CR CNRS, Team leader

Contact Informations

Phone : 33 4 68 88 73 14
Mail(s) : anne-marie.geneviere@obs-banyuls.fr

Function and attachment

 Responsable d’équipe ; FRE3355-CNRS/UPMC , CNRS section 26

Career

2000- : Responsable de l’équipe « Régulation des mécanismes cellulaires au cours du développement » ; Observatoire Océanologique de Banyuls (OOB), Laboratoire Arago-CNRS/Université Paris VI, Banyuls-sur-mer
1990-2000: CR1-CNRS Equipe Cycle Cellulaire, UMR 7628, OOB, Banyuls-sur-Mer
1981-1989 : Institut de Biochimie Cellulaire et Neurochimie, CNRS (Actuel IBGC, UPR 9026), Bordeaux, thèse d’état
1982 : Recrutement Chargée de Recherches CNRS
1978-1981: Laboratoire de Psychophysiologie (Pr. B. Cardo), thèse de troisième cycle
1977-1978: Centre de Neurochimie, Université Louis Pasteur, Strasbourg, DEA

Autres expériences professionnelles :
1997-1998 : En détachement au Friedrich Miescher Institut, Novartis, Bâle, Suisse
1987-1989: En détachement au Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS-Gif-sur-Yvette

Publications

 1.    Aze, A., C. Fayet, L. Lapasset, and A.M. Geneviere, Replication origins are already licensed in G1 arrested unfertilized sea urchin eggs. Dev. Biol., 2010. in press PMID: 20153311.
2.    Simon-Levert, A., C. Menniti, L. Soulère, A.M. Geneviere, C. Barthomeuf, B. Banaigs, and A. Witzcak, Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Mar. Drugs., 2010. 8: p. 347-358.
3.    Genevière, A.M., A. Aze, Y. Even, M. Imschenetzky, C. Nervi, and L. Vitelli, Cell dynamics in early embryogenesis and pluripotent embryonic cell lines: from sea urchin to mammals. Stem cells in marine organisms, ed. B. Rinkevich and V. Matranga. 2009: Springer-Verlag.
4.    Morin, V., A. Sanchez, K. Quinones, J.G. Huidobro, C. Iribarren, P. Bustos, M. Puchi, A.M. Geneviere, and M. Imschenetzky, Cathepsin L inhibitor I blocks mitotic chromosomes decondensation during cleavage cell cycles of sea urchin embryos. J Cell Physiol, 2008. 216(3): p. 790-5.
5.    Berro, R., C. Pedati, K. Kehn-Hall, W. Wu, Z. Klase, Y. Even, A.M. Geneviere, T. Ammosova, S. Nekhai, and F. Kashanchi, CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing. J Virol, 2008. 82(14): p. 7155-66.
6.    Simon-Levert, A., A. Aze, N. Bontemps-Subielos, B. Banaigs, and A.M. Geneviere, Antimitotic activity of methoxyconidiol, a meroterpene isolated from an ascidian. Chem Biol Interact, 2007. 168(2): p. 106-16.
7.    Geneviere, A.M., A. Aze, and Y. Even, [Genome sequencing in the sea urchin embryo: what is new concerning the cell cycle?]. J Soc Biol, 2007. 201(1): p. 31-40.
8.    Fuentes, M., E. Benito, S. Bertrand, M. Paris, A. Mignardot, L. Godoy, S. Jimenez-Delgado, D. Oliveri, S. Candiani, E. Hirsinger, S. D'Aniello, J. Pascual-Anaya, I. Maeso, M. Pestarino, P. Vernier, J.F. Nicolas, M. Schubert, V. Laudet, A.M. Geneviere, R. Albalat, J. Garcia Fernandez, N.D. Holland, and H. Escriva, Insights into spawning behavior and development of the European amphioxus (Branchiostoma lanceolatum). J Exp Zool B Mol Dev Evol, 2007. 308(4): p. 484-93.
9.    Chen, H.H., Y.H. Wong, A.M. Geneviere, and M.J. Fann, CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Biochem Biophys Res Commun, 2007. 354(3): p. 735-40.
10.    Zhang, W.L., P. Huitorel, A.M. Geneviere, S. Chiri, and B. Ciapa, Inactivation of MAPK in mature oocytes triggers progression into mitosis via a Ca2+ -dependent pathway but without completion of S phase. J Cell Sci, 2006. 119(Pt 17): p. 3491-501.
11.    Sodergren, E., G.M. Weinstock, E.H. Davidson, R.A. Cameron, R.A. Gibbs, R.C. Angerer, et al., The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science, 2006. 314(5801): p. 941-952.
12.    Puchi, M., K. Quinones, C. Concha, C. Iribarren, P. Bustos, V. Morin, A.M. Geneviere, and M. Imschenetzky, Microinjection of an antibody against the cysteine-protease involved in male chromatin remodeling blocks the development of sea urchin embryos at the initial cell cycle. J Cell Biochem, 2006. 98(2): p. 335-42.
13.    Morin, V., C. Concha, M. Puchi, A.M. Geneviere, and M. Imschenetzky, Localization CDK2/cyclin E after fertilization in zygotes treated with 3 amino-benzamide (3-ABA). Placenta, 2006. 27(1): p. A70.
14.    Imschenetzky, M., C. Concha, K. Quinones, C. Iribarren, M.I. Oliver, V. Morin, A.M. Geneviere, and M. Puchi, Localization of an antibody against the cysteine-protease involved in male chromatin remodeling after fertilization and impact of its inhibition on the initial cell embryonic division. Placenta, 2006. 27(1): p. A6.
15.    Fernandez-Guerra, A., A. Aze, J. Morales, O. Mulner-Lorillon, B. Cosson, P. Cormier, C. Bradham, N. Adams, A.J. Robertson, W.F. Marzluff, J.A. Coffman, and A.M. Geneviere, The genomic repertoire for cell cycle control and DNA metabolism in S. purpuratus. Dev Biol, 2006. 300(1): p. 238-51.
16.    Even, Y., S. Durieux, M.L. Escande, J.C. Lozano, G. Peaucellier, D. Weil, and A.M. Geneviere, CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. J Cell Biochem, 2006. 99(3): p. 890-904.
17.    Bradham, C.A., K.R. Foltz, W.S. Beane, M.I. Arnone, F. Rizzo, J.A. Coffman, A. Mushegian, M. Goel, J. Morales, A.M. Geneviere, F. Lapraz, A.J. Robertson, H. Kelkar, M. Loza-Coll, I.K. Townley, M. Raisch, M.M. Roux, T. Lepage, C. Gache, D.R. McClay, and G. Manning, The sea urchin kinome: A first look. Dev Biol, 2006. 300(1): p. 180-93.
18.    Concha, C., V. Morin, P. Bustos, A.M. Geneviere, M.M. Heck, M. Puchi, and M. Imschenetzky, Cysteine-protease involved in male chromatin remodeling after fertilization co-localizes with alpha-tubulin at mitosis. J Cell Physiol, 2005. 202(2): p. 602-7.
19.    Concha, C., A. Monardes, Y. Even, V. Morin, M. Puchi, M. Imschenetzky, and A.M. Geneviere, Inhibition of cysteine protease activity disturbs DNA replication and prevents mitosis in the early mitotic cell cycles of sea urchin embryos. J Cell Physiol, 2005. 204(2): p. 693-703.
20.    Hansen, E., Y. Even, and A.M. Geneviere, The alpha, beta, gamma, delta-unsaturated aldehyde 2-trans-4-trans-decadienal disturbs DNA replication and mitotic events in early sea urchin embryos. Toxicol Sci, 2004. 81(1): p. 190-7.
21.    Oliver, M.I., C. Rodriguez, P. Bustos, V. Morin, S. Gutierrez, M. Montecino, A.M. Geneviere, M. Puchi, and M. Imschenetzky, Conservative segregation of maternally inherited CS histone variants in larval stages of sea urchin development. J Cell Biochem, 2003. 88(4): p. 643-9.
22.    Hansen, E., H.C. Eilertsen, A. Ernstsen, and A.M. Geneviere, Anti-mitotic activity towards sea urchin embryos in extracts from the marine haptophycean Phaeocystis pouchetii (Hariot) Lagerheim collected along the coast of northern Norway. Toxicon, 2003. 41(7): p. 803-12.
23.    Marques, F., J.L. Moreau, G. Peaucellier, J.C. Lozano, P. Schatt, A. Picard, I. Callebaut, E. Perret, and A.M. Geneviere, A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs. Biochem Biophys Res Commun, 2000. 279(3): p. 832-7.
24.    Torrejon, M., A.M. Geneviere, M.V. Hinrichs, and J. Olate, The C2 cytosolic loop pf adenylyl cyclase interacts with the activated form of G alpha protein. Mol Biol Cell, 1998. 9(supplement): p. 121A.
25.    Torrejon, M., A.M. Geneviere, V. Echeverria, L. Guzman, M.V. Hinrichs, and J. Olate, The C2 cytosolic loop of adenylyl cyclase interacts with the activated form of G alpha s. FEBS Lett, 1998. 441(3): p. 437-40.
26.    Pagnac, C., A.M. Geneviere, J.M. Moreau, A. Picard, J. Joussot-Dubien, and B. Veyret, No effects of DC and 60-Hz AC magnetic fields on the first mitosis of two species of sea urchin embryos. Bioelectromagnetics, 1998. 19(8): p. 494-7.
27.    Moreau, J.L., F. Marques, A. Barakat, P. Schatt, J.C. Lozano, G. Peaucellier, A. Picard, and A.M. Geneviere, Cdk2 activity is dispensable for the onset of DNA replication during the first mitotic cycles of the sea urchin early embryo. Dev Biol, 1998. 200(2): p. 182-97.
28.    Lozano, J.C., P. Schatt, F. Marques, G. Peaucellier, P. Fort, J.P. Feral, A.M. Geneviere, and A. Picard, A presumptive developmental role for a sea urchin cyclin B splice variant. J Cell Biol, 1998. 140(2): p. 283-93.
29.    Delalande, C., A. Monnier, O. Minella, A.M. Geneviere, O. Mulner-Lorillon, R. Belle, and P. Cormier, Developmental regulation of elongation factor-1 delta in sea urchin suggests appearance of a mechanism for alternative poly(A) site selection in gastrulae. Exp Cell Res, 1998. 242(1): p. 228-34.
30.    Geneviere-Garrigues, A.M., A. Barakat, M. Doree, J.L. Moreau, and A. Picard, Active cyclin B-cdc2 kinase does not inhibit DNA replication and cannot drive prematurely fertilized sea urchin eggs into mitosis. J Cell Sci, 1995. 108 ( Pt 7): p. 2693-703.
31.    Barakat, A., A.M. Geneviere-Garrigues, P. Schatt, and A. Picard, Subcellular distribution of aster-nucleated microtubule length- A more-or-less mitotic status of cytoplasmic areas during meriosis-I of starfish oocytes. Biol of the Cell, 1994. 81(3): p. 205-13.
32.    Devault, A., D. Fesquet, J.C. Cavadore, A.M. Garrigues, J.C. Labbe, T. Lorca, A. Picard, M. Philippe, and M. Doree, Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2. J Cell Biol, 1992. 118(5): p. 1109-20.
33.    Randle, J.C., P. Vernier, A.M. Garrigues, and E. Brault, Properties of the kainate channel in rat brain mRNA injected Xenopus oocytes: ionic selectivity and blockage. Mol Cell Biochem, 1988. 80(1-2): p. 121-32.
34.    Taghzouti, K., A.M. Garrigues, J. Labouesse, M. Le Moal, and H. Simon, Bovine serum albumin--haloperidol as a tool for the study of dopaminergic transmission: behavioural and neurochemical effects following a single injection in the nucleus accumbens. Life Sci, 1987. 40(2): p. 127-37.
35.    Garrigues, A.M., F. Gehelmann, J.M. Girault, M. Delaage, and J. Labouesse, Haloperidol-succinylglycyl[125I]iodotyrosine, a novel iodinated ligand for dopamine D2 receptors. FEBS Lett, 1987. 224(2): p. 267-71.
36.    Garrigues, A.M., L. Stinus, K. Taghzouti, H. Simon, M. Le Moal, and M. Delaage, A novel long-lasting dopamine receptor blocker: haloperidol-bovine serum albumin conjugate. Eur J Pharmacol, 1985. 118(3): p. 313-9.
37.    Garrigues, A.M. and P. Cazala, Central catecholamine metabolism and hypothalamic self-stimulation behaviour in two inbred strains of mice. Brain Res, 1983. 265(2): p. 265-71.
38.    Cazala, P. and A.M. Garrigues, Effects of apomorphine, clonidine or 5-methoxy-NN-dimethyltryptamine on approach and escape components of lateral hypothalamic and mesencephalic central gray stimulation in two inbred strains of mice. Pharmacol Biochem Behav, 1983. 18(1): p. 87-93.
39.    Cazala, P. and A.M. Garrigues, Differential aversive effects of mesencephalic central gray stimulation in two inbred strains of mice. Behav Neural Biol, 1981. 32(1): p. 114-20.
40.    Cazala, P. and A.M. Garrigues, An apparent genetic relationship between appetitive and aversive effects of lateral hypothalamic stimulation in the mouse. Physiol Behav, 1980. 25(3): p. 357-61

Frequented establishments

 Observatoire Océanologique de Banyuls (OOB), Laboratoire Arago-CNRS/Université Paris VI, Banyuls-sur-mer

French and foreign diplomas

 Thèse d'Etat es Sciences, Université de Bordeaux II, 1989
             Récepteurs dopaminergiques: recherche d’une connaissance moléculaire.
Thèse de troisième cycle, Neurosciences, Université de Bordeaux I, 1981
Réponse d’approche et réponse de fuite induites par stimulation cérébrale chez deux lignées de souris consanguines: étude comportementale, pharmacologique, biochimique.
DEA de Biologie Moléculaire, option Neurochimie, Université Louis Pasteur, Strasbourg, 1978
Diplôme d’Ingénieur, Ecole Nationale Supérieure de Chimie, Strasbourg, 1977

Clubs, learned societies and associations

Société Française de Biochimie et Biologie moléculaire

15/04/16